Once you have run both of them one time, getting rid of all the gunk they find, cycle your computer off and on again and run both programs again before you run anything else, again, allowing them to do their thing.
Finally, run the immunize and lock procedures in SpyBot.
Next, right-click on the IE icon on your desktop, set the homepage you wish, close out and all should be okay.
I run ad-aware and spybot weekly.
~ GaySatyr

